Cancer is a cellular malfunction. Noni works at the cellular level to treat and cure cancer. It helps prevent proliferation of cancer cell by preventing cell mitosis. The sooner a cancer is detected, the greater are its chances of remission. Noni helps fight the cancer in the following ways: (A) By its anti carcinogenic agent Noni juice contains 150 neutraceuticals. Among them five have been shown to fight cancer. (1) Polysaccharides Polysaccharides are found abundant in Noni. Polysaccharides block the adhesion of mutated cells to other cells, thus stopping metastasis. Blocking the adhesion of mutated cells to new cell depends on the density of the polysaccharides sulphate groups, their molecular weight, and their carbohydrate structure. (2) Anthraquinones • Damnacanthal, an anthraquinone, inhibits the growth of malignant cells. • Alizarin, another anthraquinone, blocks the blood circulation to the malignant tumors, thus preventing its growth. • Anthraquinone reduces the cytochrome c (a hem-protein whose main function is electron transport using the hem prosthetic group. It act as a cancer causing agent in the body) inside the body without causing the formation of any new free radicals. (Source – from the research study conducted by group of scientist in Japan 1990) (3) Epigollocatechin gallate (EGCg) • EGCg is a polyphenolic flavonoid antioxidant found in abundant in Noni. • EGCg prevent the growth of malignant cells and so induce apoptosis. • The enzyme NOX is active in the cancer cell all the time. In a normal cell, the NOX is activated only during the cell division in response to growth hormone signal. The EGCg interferes with the tumor associated activity of NOX. (Source – from the research study on Noni juice) (4) Terpenes compound • Terpenes help in preventing the proliferation of malignant cells and induce apoptosis. • Limonene, a cyclic terpene, has been found to prevent carcinoma of mammary, liver, and lungs, and also found effective in treating leukemia. • Beta carotene, another terpene, helps to stimulate thymus gland to secrete more T- cells that destroy the carcinoma cells. • Ursolic acid, a pentacyclic triterpenoid, has anti-carcinogenic effect, both externally and internally. It is known to prevent the growth of cancerous cell and to induce apoptosis. (Source- research conducted by the National Cancer Institute, Finland) (5) Proxeronine Dr.Heinicke’s theory suggests that xeronine (conversion from proxeronine by the enzyme proxeroninase) combines with various biochemicals and building blocks i.e. hormones, proteins, enzymes, serotonins, vitamins, minerals, and antioxidants at intracellular level. The Golgi apparatus and reticulo-endothelium then assemble the necessary compounds into a specific ‘package’. This ‘package’ is sent from healthy cells to deranged cells to help in regeneration or rebuilding the damaged cells. (B) By modulating the immune process of the body Noni helps to modulate the production, activity, and effectiveness of some immune system agents. These are: • Nitric oxide: Nitric oxide, produced by activated macrophages, plays a role in the host protection against pathogen as well as malignant tumor. Noni increases the body’s biosynthesis of nitric oxide. • Interleukin: Noni modulates the production, activity, and effectiveness of interleukin-2 that enhances the production of B-cell antibodies and also the cyto-toxicity character of Natural Killer (NK) cells. • Interferon-y: Noni modulates the production and activity of interferon-y that helps in the activation of macrophages and the over all process of cell mediated immunity. (Source- Dr. Hirajumi report) • Tumor necrosis factor (TNF): Tumor necrosis factor from various macrophages destroys the malignant cells. Noni modulates the production and activity of TNF from the macrophages. • Lipopolysachrides (LPS): The LPS in serum stimulate the body’s immune process to eliminate any pathogens. Noni helps modulate the production of LPS in serum thus increasing the immune process of the body. • Natural killer cells (NK cells): Noni helps modulate the production of NK cells that destroys the malignant cells. Thus, Noni juice is multifaceted in its approach to fight cancer.